Matteo Di Bernardo, Claire Peterson, Ege Topkoc, Matt Might, Iain M. Cheeseman · 2026 · arXiv (Cornell University)
DOI: 10.48550/arxiv.2610.22617 · cited by 0 works (OpenAlex) · open-access PDF
Lang etablierte optische Festbildschirme verbinden genetische Störungen mit Veränderungen in Zellmorphologie und Verhalten, aber die Umwandlung der Mikroskopie-Daten in interpretierbare Ergebnisse erfordert komplexe, mehrtägige Analysen. etablierte Pipelines verarbeiten diese Daten, aber Forscher wählen immer noch Parameter, inspizieren Ausgänge und lösen Fehler für jedes Experiment. Hier präsentieren wir Brieflow-auto, eine Pipeline-spezifische Verwendung, die als ein Claude Code-Plugin implementiert wird, das ein Codierungsgroßsprachenmodell (LLM) ermöglicht, Brieflow zu betreiben, eine Open-Source-End-to-End-Pipeline für optische Screening-Daten. Ein Forscher liefert experimentelle Fakten und gene
Machine translation (Meta M2M100); the English original follows.
Optical pooled screens connect genetic perturbations to changes in cell morphology and behavior, but turning the microscopy data into interpretable results takes complex, multi-day analyses. Established pipelines process this data, yet researchers still select parameters, inspect outputs, and resolve failures for each experiment. Here, we present Brieflow-auto, a pipeline-specific harness implemented as a Claude Code plugin that lets a coding large language model (LLM) operate Brieflow, an open-source end-to-end pipeline for optical pooled screening data. A researcher supplies experimental facts and approves the launch. An agent tunes parameters in an interactive notebook, and the harness validates the configuration, monitors execution, recovers from common failures, and checks output quality. For pipeline defects, the agent opens upstream issues proposing backward-compatible fixes for the broader community. In five previously analyzed screens, harness runs yielded more cells with a confident single-gene assignment than the original hand analyses. On a screen the pipeline was not designed for, the harness turned each failure into a reviewed upstream fix. More broadly, we propose that wrapping an established pipeline in a harness can substantially accelerate its use and the long-term reliability of its codebase.
Read in: English · Spanish · Chinese · Hindi · Arabic · Portuguese · French · German · Japanese · Russian · Korean · Indonesian · Vietnamese
Topics: Pipeline (software), Coding (social sciences), Computer science, Process (computing), Reliability (semiconductor), Upstream (networking)
GET https://store.agentexchange.work/gw/papers/verify?title=...&year=... (0.003 USD), fetch this record as JSON with /gw/papers/paper?id=2610.22617, or list what it cites with /gw/papers/references?id=.... Pay per call in USDC (x402) or with a 19 USD card key for 1,000 calls. Catalogue · llms.txtSources: OpenAlex (CC0), arXiv, Crossref. Agent Exchange