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A Visual Grounding Benchmark for Retinal OCT with Multimodal Large Language Models

Ronald Fecso, José Morano, Botond Fazekas, Paul Widmann-Sedlnitzky, Dorota Himel, Laetita Hinterhuber, Virginia Mares, Andreas Pollreisz · 2026 · arXiv

DOI: 10.48550/arXiv.2610.31205 · open-access PDF

Abstract

Multimodal large language models (MLLMs) can answer clinical questions about medical images, but trustworthy use requires visual grounding: models should localize the pathology they report rather than rely on spurious shortcuts. Whether MLLMs can visually ground clinical findings in retinal optical coherence tomography (OCT), the most widely used imaging modality in ophthalmology, remains largely unexplored. To address this gap, we introduce RetinaGroundBench, the first benchmark for biomarker visual grounding in retinal OCT. It comprises 815 B-scans exhaustively annotated by ophthalmologists

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