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An Open Reliability Atlas of Sensitivity and Failure Modes in the Pulse Physiology Engine

Santino Nanini, Arnaud Wiedemann, Yassir Mamouni, Cyril Schweitzer, Philippe A. Jouvet, Michael Sauthier · 2026 · arXiv (Cornell University)

DOI: 10.48550/arxiv.2610.28517 · cited by 0 works (OpenAlex) · open-access PDF

Arabic

إن Pulse هو نموذجًا مفتوحًا للموارد البشرية المفتوحة، ومع ذلك، فإن الموارد البشرية لا تقرأ تحليلًا رسميًا لحساسية إمداداتها التشغيلية. نحن نقدم أول نموذجًا مفتوحًا للتأكد في جميع أنحاء حزمة الرعاية الأساسية: نموذج نموذج موريس الأساسية من سبعة إمدادات، أربعة سيناريوهات شديدة، أجسام الرجال والنساء (1،280 نموذجًا). الحساسية مجهولة: ثلاث إمدادات تحمل 93% المتوسط من مجموع كل إمداد. يظهر نموذج أربعة الأسماك نموذجًا من الفشل: اثنين من المرشحين، واحدة من الجنسين. نموذ

Machine translation (Meta M2M100); the English original follows.

Abstract

Pulse is an actively maintained open-source adult-physiology simulator, yet its maintainers report no formal sensitivity analysis of its operational inputs. We present the first open reliability atlas across its critical-care envelope: Morris elementary-effects sampling of seven inputs, four severity scenarios, male and female bodies (1,280 simulations). Sensitivity is skewed: three inputs carry a median 93% of each output's total. A four-flag classifier reveals failure modes: two operator-actionable, one sex-stratified. Tidal-volume oscillation (20.6% of runs) is consistent with patient-ventilator dyssynchrony; locking the VC-AC trigger to -2 cmH2O collapses that variability. At FiO2 = 1.0, transient hyperoxia makes 120-second runs underestimate plateau PaO2; 300-second healthy-lung reruns give a median 643 mmHg. Solver divergence was all-male in an input-extreme regime (20/1,280); reducing the male blood-volume baseline to the 4,082 mL floor eliminated it. Runs and flags are released openly, showing users which regions need checking before training on Pulse output.

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Topics: Computer science, Sensitivity (control systems), Atlas (anatomy), Pulse (music), Reliability (semiconductor), Acoustics

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