An Open Reliability Atlas of Sensitivity and Failure Modes in the Pulse Physiology Engine

Santino Nanini, Arnaud Wiedemann, Yassir Mamouni, Cyril Schweitzer, Philippe Jouvet, Michael Sauthier · 2026 · arXiv

DOI: 10.48550/arXiv.2610.28517 · open-access PDF

Portuguese

O Pulse é um simulador de fisiologia adulta de código aberto ativamente mantido, mas seus mantenedores não reportam nenhuma análise formal de sensibilidade de suas entradas operacionais. Nós apresentamos o primeiro atlas de confiabilidade aberto em todo o seu envelope de cuidados críticos: amostragem de efeitos elementares de Morris de sete entradas, quatro cenários de gravidade, corpos masculino e feminino (1,280 simulações). A sensibilidade é distorcida: três entradas carregam uma média de 93% do total de cada saída. Um classificador de quatro bandeiras revela modos de falha: dois operadores-accionáveis, um sex-stratificado. A oscilação de volume de Tidal (20,6% de corridas) é consistente com o desempenho do paciente

Machine translation (Meta M2M100); the English original follows.

Abstract

Pulse is an actively maintained open-source adult-physiology simulator, yet its maintainers report no formal sensitivity analysis of its operational inputs. We present the first open reliability atlas across its critical-care envelope: Morris elementary-effects sampling of seven inputs, four severity scenarios, male and female bodies (1,280 simulations). Sensitivity is skewed: three inputs carry a median 93% of each output's total. A four-flag classifier reveals failure modes: two operator-actionable, one sex-stratified. Tidal-volume oscillation (20.6% of runs) is consistent with patient-venti

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