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An Open Reliability Atlas of Sensitivity and Failure Modes in the Pulse Physiology Engine

Santino Nanini, Arnaud Wiedemann, Yassir Mamouni, Cyril Schweitzer, Philippe A. Jouvet, Michael Sauthier · 2026 · arXiv (Cornell University)

DOI: 10.48550/arxiv.2610.28517 · cited by 0 works (OpenAlex) · open-access PDF

Spanish

Pulse es un simulador de fisiología adulta de código abierto que se mantiene activamente, sin embargo sus mantenedores no reportan análisis de sensibilidad formal de sus entradas operativas. Presentamos el primer atlas de fiabilidad abierta a través de su envoltorio de cuidado crítico: Morris elementary-effects sampling de siete entradas, cuatro escenarios de severidad, cuerpos masculinos y femeninos (1,280 simulaciones). La sensibilidad está distorsionada: tres entradas llevan un 93% mediano del total de cada salida. Un clasificador de cuatro bandas revela modos de fracaso: dos operadores-accionables, uno sex-stratificado. La oscilación del volumen de Tidal en la placa PaO 3002O; los usuarios son consistentes con la disíncronía del ventilador paciente-segundo; bloquear

Machine translation (Meta M2M100); the English original follows.

Abstract

Pulse is an actively maintained open-source adult-physiology simulator, yet its maintainers report no formal sensitivity analysis of its operational inputs. We present the first open reliability atlas across its critical-care envelope: Morris elementary-effects sampling of seven inputs, four severity scenarios, male and female bodies (1,280 simulations). Sensitivity is skewed: three inputs carry a median 93% of each output's total. A four-flag classifier reveals failure modes: two operator-actionable, one sex-stratified. Tidal-volume oscillation (20.6% of runs) is consistent with patient-ventilator dyssynchrony; locking the VC-AC trigger to -2 cmH2O collapses that variability. At FiO2 = 1.0, transient hyperoxia makes 120-second runs underestimate plateau PaO2; 300-second healthy-lung reruns give a median 643 mmHg. Solver divergence was all-male in an input-extreme regime (20/1,280); reducing the male blood-volume baseline to the 4,082 mL floor eliminated it. Runs and flags are released openly, showing users which regions need checking before training on Pulse output.

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Topics: Computer science, Sensitivity (control systems), Atlas (anatomy), Pulse (music), Reliability (semiconductor), Acoustics

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