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An Open Reliability Atlas of Sensitivity and Failure Modes in the Pulse Physiology Engine

Santino Nanini, Arnaud Wiedemann, Yassir Mamouni, Cyril Schweitzer, Philippe A. Jouvet, Michael Sauthier · 2026 · arXiv (Cornell University)

DOI: 10.48550/arxiv.2610.28517 · cited by 0 works (OpenAlex) · open-access PDF

Indonesian

Pulse adalah simulator fisiologi dewasa open-source yang secara aktif dipelihara, namun pemeliharanya tidak melaporkan analisis sensitivitas formal dari input operasionalnya. Kami menyajikan atlas keandalan terbuka pertama di seluruh kemasan perawatan kritisnya: Morris elementary-effects sampling dari tujuh input, empat skenario keparahan, tubuh laki-laki dan perempuan (1,280 simulasi). Sensitivitas terganggu: tiga input membawa median 93% dari total setiap output. Sebuah klasifikator empat bendera mengungkapkan mode kegagalan: dua operator-aktif, satu sex-stratified. Tidal-volume oscillation (20.6% dari run) konsisten dengan dysynchrony pasien-ventilator; mengunci trigger VCAC ke -2 cmH2O menghancurkan variabilitas itu. Pada FiO2 = 1.0, hyperoxia trans

Machine translation (Meta M2M100); the English original follows.

Abstract

Pulse is an actively maintained open-source adult-physiology simulator, yet its maintainers report no formal sensitivity analysis of its operational inputs. We present the first open reliability atlas across its critical-care envelope: Morris elementary-effects sampling of seven inputs, four severity scenarios, male and female bodies (1,280 simulations). Sensitivity is skewed: three inputs carry a median 93% of each output's total. A four-flag classifier reveals failure modes: two operator-actionable, one sex-stratified. Tidal-volume oscillation (20.6% of runs) is consistent with patient-ventilator dyssynchrony; locking the VC-AC trigger to -2 cmH2O collapses that variability. At FiO2 = 1.0, transient hyperoxia makes 120-second runs underestimate plateau PaO2; 300-second healthy-lung reruns give a median 643 mmHg. Solver divergence was all-male in an input-extreme regime (20/1,280); reducing the male blood-volume baseline to the 4,082 mL floor eliminated it. Runs and flags are released openly, showing users which regions need checking before training on Pulse output.

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Topics: Computer science, Sensitivity (control systems), Atlas (anatomy), Pulse (music), Reliability (semiconductor), Acoustics

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