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An Open Reliability Atlas of Sensitivity and Failure Modes in the Pulse Physiology Engine

Santino Nanini, Arnaud Wiedemann, Yassir Mamouni, Cyril Schweitzer, Philippe A. Jouvet, Michael Sauthier · 2026 · arXiv (Cornell University)

DOI: 10.48550/arxiv.2610.28517 · cited by 0 works (OpenAlex) · open-access PDF

Hindi

पल्स एक सक्रिय रूप से बनाए रखे गए खुले स्रोत वयस्क भौतिक विज्ञान सिमुलेटर है, फिर भी इसके रखरखावकर्ताओं को अपने संचालन इनपुट के लिए कोई आधिकारिक संवेदनशीलता विश्लेषण की रिपोर्ट नहीं है। हम अपने महत्वपूर्ण देखभाल कवर के माध्यम से पहला खुले विश्वसनीयता अटलास प्रस्तुत करते हैं: मॉरिस प्राथमिक प्रभाव सात इनपुट, चार गंभीरता परिदृश्यों, पुरुषों और महिलाओं के शरीर (1,280 सिमुलेशन) के नमूने। संवेदनशीलता विकृत है: तीन इनपुट प्रत्येक आउटपुट के कुल का मध्यम 93% लेते हैं। एक चार झंडा वर्गीकरण विफलता मोडों को प्रकट करता है: दो ऑपरेटर-अनुकूल, एक लिंग-स्ट्रेडिंग। टाइडल-

Machine translation (Meta M2M100); the English original follows.

Abstract

Pulse is an actively maintained open-source adult-physiology simulator, yet its maintainers report no formal sensitivity analysis of its operational inputs. We present the first open reliability atlas across its critical-care envelope: Morris elementary-effects sampling of seven inputs, four severity scenarios, male and female bodies (1,280 simulations). Sensitivity is skewed: three inputs carry a median 93% of each output's total. A four-flag classifier reveals failure modes: two operator-actionable, one sex-stratified. Tidal-volume oscillation (20.6% of runs) is consistent with patient-ventilator dyssynchrony; locking the VC-AC trigger to -2 cmH2O collapses that variability. At FiO2 = 1.0, transient hyperoxia makes 120-second runs underestimate plateau PaO2; 300-second healthy-lung reruns give a median 643 mmHg. Solver divergence was all-male in an input-extreme regime (20/1,280); reducing the male blood-volume baseline to the 4,082 mL floor eliminated it. Runs and flags are released openly, showing users which regions need checking before training on Pulse output.

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Topics: Computer science, Sensitivity (control systems), Atlas (anatomy), Pulse (music), Reliability (semiconductor), Acoustics

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