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An Open Reliability Atlas of Sensitivity and Failure Modes in the Pulse Physiology Engine

Santino Nanini, Arnaud Wiedemann, Yassir Mamouni, Cyril Schweitzer, Philippe A. Jouvet, Michael Sauthier · 2026 · arXiv (Cornell University)

DOI: 10.48550/arxiv.2610.28517 · cited by 0 works (OpenAlex) · open-access PDF

Korean

Pulse는 활발하게 유지되는 오픈 소스 성인 생리학 시뮬레이터이지만 유지 관리자는 운영 입력에 대한 공식적인 민감성 분석을보고하지 않습니다. 우리는 중요한 보살핌 포장에 걸쳐 첫 번째 오픈 신뢰성 아틀라스를 제시합니다 : 모리스 원본 효과는 7 개의 입력, 4 개의 심각성 시나리오, 남성과 여성 신체 (1,280 시뮬레이션)를 샘플링합니다. 민감성은 왜곡됩니다 : 3 개의 입력은 각 출력의 총 중간 93%를 가져옵니다. 4 개의 깃발 분류기는 실패 모드를 밝힙니다 : 두 개의 운영자-행동, 하나의 성-층화. Tidal 볼륨 진동 (20.6 %의 실행)은 환자 - 밸런터 dysynchrony와

Machine translation (Meta M2M100); the English original follows.

Abstract

Pulse is an actively maintained open-source adult-physiology simulator, yet its maintainers report no formal sensitivity analysis of its operational inputs. We present the first open reliability atlas across its critical-care envelope: Morris elementary-effects sampling of seven inputs, four severity scenarios, male and female bodies (1,280 simulations). Sensitivity is skewed: three inputs carry a median 93% of each output's total. A four-flag classifier reveals failure modes: two operator-actionable, one sex-stratified. Tidal-volume oscillation (20.6% of runs) is consistent with patient-ventilator dyssynchrony; locking the VC-AC trigger to -2 cmH2O collapses that variability. At FiO2 = 1.0, transient hyperoxia makes 120-second runs underestimate plateau PaO2; 300-second healthy-lung reruns give a median 643 mmHg. Solver divergence was all-male in an input-extreme regime (20/1,280); reducing the male blood-volume baseline to the 4,082 mL floor eliminated it. Runs and flags are released openly, showing users which regions need checking before training on Pulse output.

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Topics: Computer science, Sensitivity (control systems), Atlas (anatomy), Pulse (music), Reliability (semiconductor), Acoustics

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